Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 131, Issue -, Pages 9-16Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2017.05.004
Keywords
CIA; CLnA; Conjugated fatty acids; Desaturases; Pomegranate seed oil; Punicic acid
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The aim of our study was to cothpare the influence of diet supplementation with pomegranate seed oil as conjugated linolenic acids (CLnA) source, or conjugated linoleic acids (CIA) and to examine the mechanism of their activity. The content of fatty acids, levels of biomarkers of lipids' oxidation and the activity of key enzymes catalyzing lipids metabolism were measured. Obtained results revealed that conjugated fatty acids significantly decrease the activity of Delta 5-desaturase (p = 0.0001) and Delta 6-desaturase (p = 0.0008) and pomegranate seed oil reduces their activity in the most potent way. We confirmed that diet supplementation with pomegranate seed oil - a rich source of punicic acid leads to the increase of cis-9, trans-11 CLA content in livers (p = 0.0003). Lack of side effects and beneficial influence on desaturases activity and fatty acids profile claim pomegranate seed oil to become interesting alternative for CLA as functional food.
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