Journal
FLUIDS AND BARRIERS OF THE CNS
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12987-018-0100-y
Keywords
Zika virus; Brain endothelial cells; Blood-brain barrier model; iPSC; AXL; Neural progenitors
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Funding
- National Research Council of Canada
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Zika virus (ZIKV) is a flavivirus that is highly neurotropic causing congenital abnormalities and neurological damage to the central nervous systems (CNS). In this study, we used a human induced pluripotent stem cell (iPSC)-derived blood brain barrier (BBB) model to demonstrate that ZIKV can infect brain endothelial cells (i-BECs) without compromising the BBB barrier integrity or permeability. Although no disruption to the BBB was observed post-infection, ZIKV particles were released on the abluminal side of the BBB model and infected underlying iPSC-derived neural progenitor cells (i-NPs). AXL, a putative ZIKV cellular entry receptor, was also highly expressed in ZIKV-susceptible i-BECand i-NPs. This iPSC-derived BBB model can help elucidate the mechanism by which ZIKV can infect BECs, cross the BBB and gain access to the CNS.
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