Journal
MICROBIAL CELL
Volume 5, Issue 5, Pages 249-255Publisher
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/mic2018.05.631
Keywords
microbial competition; Escherichia coli; Candida albicans; antifungal; magnesium
Categories
Funding
- National Institute of General Medical Sciences of the National Institutes of Health through the IDeA Network of Biomedical Research (INBRE) program [P20GM103430]
- CONACyT [221332, 279957]
- National Science Foundation Graduate Research Fellowship [1644760]
- Center for Computational Biology of Human Disease [NIH P20 GM109035]
- Paicyt Science Grant from the Universidad Autononna de Nuevo Leon
- Fronteras de la Ciencia [1502]
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Localized and systemic fungal infections caused by Candida albicans can lead to significant mortality and morbidity. However, severe C. albicans infections are relatively rare, occurring mostly in the very young, the very old, and immunocompromised individuals. The fact that these infections are rare is interesting because as much as 80 percent of the population is asymptomatically colonized with C. albicans. It is thought that members of the human microbiota and the immune system work in concert to reduce C. albicans overgrowth through competition and modification of the growth environment. Here, we report that Escherichia coli (strain MG1655) outcompetes and kills C. albicans (strain SC5314) in vitro. We find that E. coli produces a soluble factor that kills C. albicans in a magnesium-dependent fashion such that depletion of available magnesium is essential for toxicity.
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