Journal
BREAST CANCER RESEARCH
Volume 20, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13058-018-0967-1
Keywords
Atypical ductal hyperplasia; Breast neoplasms; Ductal carcinoma in situ; Breast cancer progression; Clonal relationship; Patient care management
Categories
Funding
- Australian National Health and Medical Research Council (NHMRC) [APP1063092]
- Melbourne International Research Scholarship
- Melbourne International Fee Remission Scholarship
- Victorian Cancer Agency Fellowship
Ask authors/readers for more resources
Background: Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportion are upgraded to carcinoma upon excision; however, the remainder of patients are overtreated. While ADH is considered a non-obligate precursor of invasive carcinoma, the molecular taxonomy remains unknown. Main text: Although a few studies have revealed some of the key genomic characteristics of ADH, a clear understanding of the molecular changes associated with breast cancer progression has been limited by inadequately powered studies and low resolution methodology. Complicating factors such as family history, and whether the ADH present in a biopsy is an isolated lesion or part of a greater neoplastic process beyond the limited biopsy material, make accurate interpretation of genomic features and their impact on progression to malignancy a challenging task. This article will review the definitions and variable management of the patients diagnosed with ADH as well as the current knowledge of the molecular landscape of ADH and its clonal relationship with ductal carcinoma in situ and invasive carcinoma. Conclusions: Molecular data of ADH remain sparse. Large prospective cohorts of pure ADH with clinical follow-up need to be evaluated at DNA, RNA, and protein levels in order to develop biomarkers of progression to carcinoma to guide management decisions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available