Journal
RHEUMATOLOGY AND THERAPY
Volume 5, Issue 1, Pages 5-20Publisher
SPRINGER
DOI: 10.1007/s40744-018-0100-z
Keywords
Autoimmunity; Behcet's disease; Celiac disease; Genotyping; Human leucocyte antigen; MHC class I; MHC class II; Shared epitopes; Spondylarthritis; Rheumatoid arthritis
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Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Beh double dagger et's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.
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