Journal
PROGRESS IN NEUROBIOLOGY
Volume 156, Issue -, Pages 149-163Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2017.05.003
Keywords
IFN gamma; Neuroimmunology; Neuroinflammation; Central nervous system; Cytokine
Categories
Funding
- Portuguese Science Foundation (FCT) [SFRH/BD/69311/2010, GN1SFRH/BPD/72710/201GNO1]
- Programa Operacional Regional do Norte (ON.2 - O Novo Norte), Quadro de Referencia Estrategico Nacional (QREN) through Fundo Europeu de Desenvolvimento Regional (FEDER)
- Programa Operacional Regional do Norte (ON.2 SR&TD Integrated Program), Quadro de Referenda Estrategico Nacional (QREN), atraves do Fundo Europeu de Desenvolvimento Regional (FEDER) [NORTE-07-0124-FEDER-000021]
- national funds from FCT [PEst-C/SAU/LA0026/2013]
- Fundo Europeu de Desenvolvimento Regional (FEDER), atraves do COMPETE [FCOMP-01-0124-FEDER-037298]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/69311/2010] Funding Source: FCT
Ask authors/readers for more resources
Interferon gamma (IFN-gamma) is a pro-inflammatory cytokine, first described as a secreted molecule capable of interfering with viral replication. Since then, numerous other important actions in the context of the immune response to invading pathogens (including those invading the brain) have been ascribed to this pleiotropic cytokine. Nevertheless, the precise role of IFN gamma in neuropsychiatric and neurodegenerative disorders, and its possible contribution to the regulation of normal brain function, remains enigmatic. This review integrates and considers current knowledge about IFN gamma actions with accumulating evidence of its importance on neurocytogenesis, synaptic plasticity and neurodegeneration within the framework of brain health and disease. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
