Journal
PROGRESS IN NEUROBIOLOGY
Volume 157, Issue -, Pages 29-48Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2017.07.003
Keywords
Nanomaterials; Neurological diseases; Blood brain barrier; Central nervous system
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Funding
- Zhejiang Provincial Natural Science Foundation [LQ15H090006]
- Chinese National Natural Science Foundation [81641045, 81371396]
- Health Bureau of Zhejiang Province [2016RCA022]
- Scientific Research Foundation of Wenzhou [Y20150042]
- American Heart Association [15PRE25700416]
- Zhejiang provincial key research project [2017C03027]
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The effectiveness of noninvasive treatment for neurological disease is generally limited by the poor entry of therapeutic agents into the central nervous system (CNS). Most CNS drugs cannot permeate into the brain parenchyma because of the blood-brain barrier thus, overcoming this problem has become one of the most significant challenges in the development of neurological therapeutics. Nanotechnology has emerged as an innovative alternative for treating neurological diseases. In fact, rapid advances in nanotechnology have provided promising solutions to this challenge. This review highlights the applications of nanomaterials in the developing neurological field and discusses the evidence for their efficacies. (C) 2017 Elsevier Ltd. All rights reserved.
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