Journal
PROGRESS IN MATERIALS SCIENCE
Volume 88, Issue -, Pages 89-135Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pmatsci.2017.03.004
Keywords
NIR nanoparticles; Up-conversion; Multiphoton; Photo-therapy; Imaging; Cancer theranostics
Categories
Funding
- Marie Curie International Outgoing Fellowship (FP7-PEOPLE-IOF) [626386]
- National Science Centre [DEC-2012/05/E/ST5/03901]
- Wroclaw Research Centre EIT + within the project The Application of Nanotechnology in Advanced Materials - NanoMat - European Regional Development Fund (Operational Programme Innovative Economy) [POIG.01.01.02-02-002/08]
- National Health Research Institutes, Taiwan [NHRI-EX105- 10427EI]
- Ministry of Science and Technology, Taiwan [MoST 104-2627- M-002 -018, MOST 105-2113-M-006 -015 -MY3]
- Taipei City Hospital (TCH)/Department of Health, Taipei City Government (TCH) [10401-62-058, 10601-62-015]
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Light-based diagnostics and therapy have become indispensable tools in the field of cancer nanomedicine. Various optical imaging modalities with tomographic capability have been developed to visualize cellular and organismic distributions of molecules. Microscopic pharmacokinetics and the tumor-targeting efficacy of nanoscale effectors can now be precisely evaluated. Moreover, phototherapy using intense laser light has been widely used for treating cancers. Using light-active nanoscale effectors, photothermal and photodynamic therapies on superficial tumors can be achieved with low-illumination lasers. Consequently, for the next generation of photo-medical techniques, the use of near infrared (NIR) excitation sources on NIR-activatable nanoparticles may offer deeper light penetration owing to less extensive scattering and absorption by endogenous chromophores in the NIR spectral region. Therefore, treatments and biodetection within higher tissue volumes and with less side effects (e.g. overheating) may be successfully implemented. This comprehensive review covers the state-of-the-art technologies on (a) advanced laser light sources appropriate for deep tissue theranostics, (b) types of laser interactions with pureNIR and NIR-upconverting nanomaterials, (c) current development of NIR and multiphoton nanoparticles, (d) application fields of NIR nanomaterials in cancer theranostics, and (e) nanotoxicology of NIR nanoscale effectors for cancer treatment. (C) 2017 Elsevier Ltd. All rights reserved.
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