Journal
CRITICAL CARE
Volume 22, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13054-018-2051-8
Keywords
Acute lung injury; Injurious mechanical ventilation; TCAV protocol
Categories
Funding
- NIH [R01 HL131143]
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The pathophysiology of acute respiratory distress syndrome (ARDS) results in heterogeneous lung collapse, edema-flooded airways and unstable alveoli. These pathologic alterations in alveolar mechanics (i.e. dynamic change in alveolar size and shape with each breath) predispose the lung to secondary ventilator-induced lung injury (VILI). It is our viewpoint that the acutely injured lung can be recruited and stabilized with a mechanical breath until it heals, much like casting a broken bone until it mends. If the lung can be casted with a mechanical breath, VILI could be prevented and ARDS incidence significantly reduced.
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