Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 10, Pages 2520-2525Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1612139114
Keywords
mechanical metamaterials; allostery; tunable response; proteins; disordered networks
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Funding
- US Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Awards [DE-FG02-05ER46199, DE-FG02-03ER46088]
- National Science Foundation Graduate fellowship
- Simons Foundation Grants [305547, 327939]
- National Institute of Standards and Technology under Award [60NANB15D055]
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Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only similar to 1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks.
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