Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 38, Pages 10262-10267Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1619657114
Keywords
aging; relational memory; optogenetics; trace conditioning; radial maze
Categories
Funding
- INSERM
- le Conseil Regional d'Aquitaine
- EquipEx Grant OptoPath [ANR-10-EQX-008-1]
- Bordeaux Science Agro
- CNRS
- National Institute of Mental Health [MH095297]
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Temporal binding, the process that enables association between discontiguous stimuli in memory, and relational organization, a process that enables the flexibility of declarative memories, are both hippocampus-dependent and decline in aging. However, how these two processes are related in supporting declarative memory formation and how they are compromised in age-related memory loss remain hypothetical. We here identify a causal link between these two features of declarative memory: Temporal binding is a necessary condition for the relational organization of discontiguous events. We demonstrate that the formation of a relational memory is limited by the capability of temporal binding, which depends on dorsal (d)CA1 activity over time intervals and diminishes in aging. Conversely, relational representation is successful even in aged individuals when the demand on temporal binding is minimized, showing that relational/declarative memory per se is not impaired in aging. Thus, bridging temporal intervals by dCA1 activity is a critical foundation of relational representation, and a deterioration of this mechanism is responsible for the age-associated memory impairment.
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