Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 16, Pages E3188-E3194Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1620457114
Keywords
hyperpolarization; SABRE; catalysis; NMR; MRI
Categories
Funding
- Wellcome Trust [092506, 098335]
- Bruker BioSpin
- University of York
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Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that ordinarily impractical measurements become possible. The potential to revolutionize analytical NMR and clinical diagnosis through this approach reflect this area's most compelling outcomes. Methods to optimize the low-cost parahydrogen-based approach signal amplification by reversible exchange with studies on a series of biologically relevant nicotin-amides and methyl nicotinates are detailed. These procedures involve specific H-2 labeling in both the agent and catalyst and achieve polarization lifetimes of ca. 2 min with 50% polarization in the case of methyl-4,6-d(2)-nicotinate. Because a 1.5-T hospital scanner has an effective H-1 polarization level of just 0.0005% this strategy should result in compressed detection times for chemically discerning measurements that probe disease. To demonstrate this technique's generality, we exemplify further studies on a range of pyridazine, pyrimidine, pyrazine, and isonicotinamide analogs that feature as building blocks in biochemistry and many disease-treating drugs.
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