Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 9, Pages 2230-2234Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1616556114
Keywords
methylation; polycomb; aging
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Funding
- European Research Council
- Israel Cancer Research Fund
- Rosetrees Foundation
- Smart Family Foundation
- Lew Sanders
- Rosetrees Trust [M31-F2, M31-F1] Funding Source: researchfish
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Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in normal cells. Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation.
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