Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 1, Pages 151-156Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1707227114
Keywords
natural selection; stabilizing selection; complex traits
Categories
Funding
- UKB Resource [12505]
- Australian Research Council [160103860]
- Australian National Health and Medical Research Council [1078037, 1113400]
- NIH [R01-GM115564]
- National Science Foundation (NSF) [DGE-1321846]
- Medical Research Council [MC_qA137853] Funding Source: researchfish
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM115564] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available