Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 48, Pages 12821-12826Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1710521114
Keywords
default mode network; cognitive flexibility; functional magnetic resonance imaging; functional connectivity; autopilot
Categories
Funding
- Yousef Jameel Academic Program grant
- National Institute for Health Research (NIHR) Cambridge Biomedical Centre [RCZB/004]
- NIHR Senior Investigator Award [RCZB/014]
- Stephen Erskine Fellowship Queens' College, Cambridge
- National Institute for Health Research [NF-SI-0512-10090] Funding Source: researchfish
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Concurrent with mental processes that require rigorous computation and control, a series of automated decisions and actions govern our daily lives, providing efficient and adaptive responses to environmental demands. Using a cognitive flexibility task, we show that a set of brain regions collectively known as the default mode network plays a crucial role in such autopilot behavior, i.e., when rapidly selecting appropriate responses under predictable behavioral contexts. While applying learned rules, the default mode network shows both greater activity and connectivity. Furthermore, functional interactions between this network and hippocampal and parahippocampal areas as well as primary visual cortex correlate with the speed of accurate responses. These findings indicate a memory-based autopilot role for the default mode network, which may have important implications for our current understanding of healthy and adaptive brain processing.
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