Journal
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
Volume 45, Issue 2, Pages 82-87Publisher
KOREAN SOC REPRODUCTIVE MEDICINE
DOI: 10.5653/cerm.2018.45.2.82
Keywords
In vitro fertilization; Mice; Offsprings; Oxidative stress; Prooxidant-antioxidant balance
Categories
Funding
- Research Deputy of Tehran University of Medical Sciences [29860]
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Objective: Concerns about the safety of assisted reproductive technology (ART) have been raised, as some studies have shown elevated incidence rates of childhood cancer, asthma, allergies, and other diseases in ART-conceived babies. Findings regarding the health of ART-conceived babies are controversial. The present study was conducted to evaluate the prooxidant-antioxidant balance (PAB) in in vitro fertilization (IVF)conceived mice in comparison to naturally conceived offspring. Methods: Mice (6-8 weeks) were divided into two groups (IVF-conceived and naturally conceived) matched by sex, age, weight, and litter size. A 1-mL blood sample was taken and the sera were separated. The oxidant-antioxidant balance was evaluated using a fast and reliable PAB assay. The results were expressed as mean +/- standard deviation. Results: The mean PAB values (HK units) in the IVF-conceived and naturally conceived groups were 59.70 +/- 22.30 and 54.70 +/- 18.22, respectively (p = 0.82). Conclusion: Since free radicals contribute to several pathological conditions and antioxidants play an important protective role against oxidative stress, evaluating the oxidant-antioxidant balance is very important. Although the results of this study showed that the quality of the defense mechanism against free radicals was not significantly different between the IVF-conceived and naturally conceived mice, other parameters of metabolic dysfunction need to be measured.
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