Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 25, Pages 6617-6622Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1702984114
Keywords
Arabidopsis; photomorphogenesis; phosphorylation; PID; COP1
Categories
Funding
- National Natural Science Foundation of China [31330048, 31621001]
- Peking-Tsinghua Center for Life Sciences
- US National Institutes of Health [GM-47850]
- Southern University of Science and Technology
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CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi to humans. As a key component in regulating various biological events, COP1 itself is precisely controlled at multiple layers. Here, we report a negative regulator of COP1, PINOID (PID), which positively mediates photomorphogenic development. Specifically, PID genetically and physically interacts with COP1 and directly phosphorylates COP1 at Ser20. As a result, this posttranslational modification serves to repress COP1 activity and promote photomorphogenesis. Our findings signify a key regulatory mechanism for precisely maintaining COP1 activity, thereby ensuring appropriate development in plants.
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