Journal
BIOINFORMATICS
Volume 34, Issue 11, Pages 1944-1946Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btx846
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Funding
- Horizon 2020 programme of the European Union, iNEXT (H2020 Grant) [653706]
- EMBL Interdisciplinary Postdoc Programme under Marie Curie COFUND Actions
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Size-exclusion chromatography (SEC) coupled to small-angle X-ray scattering (SAXS), also known as inline SEC-SAXS, is being increasingly used for the structural analysis of biological macromolecules, complexes and mixtures in solution. A single SEC-SAXS run generates thousands of individual SAXS profiles from the eluting solute and their analysis requires a correct identification of buffer and sample regions, a rather laborous task. We present CHROMIXS (as in CHROMatography Inline X-ray Scattering), a program for rapid reduction and analysis, both automatically and interactively, of SEC-SAXS data.
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