Journal
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
Volume 5, Issue 1, Pages 2-14Publisher
INT JOURNAL PARTICLE THERAPY
DOI: 10.14338/IJPT-18-00011.1
Keywords
proton therapy; relative biological effectiveness; proton dose response
Funding
- National Institutes of Health [NCI U19 CA21239]
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Proton therapy treatments are prescribed using a biological effectiveness relative to photon therapy of 1.1, that is, proton beams are considered to be 10% more biologically effective. Debate is ongoing as to whether this practice needs to be revised. This short review summarizes current knowledge on relative biological effectiveness variations and uncertainties in vitro and in vivo. Clinical relevance is discussed and strategies toward biologically guided treatment planning are presented.
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