Related references
Note: Only part of the references are listed.Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Eri H. Kobayashi et al.
NATURE COMMUNICATIONS (2016)
SIRT2-and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models
Luisa Quinti et al.
CELL CHEMICAL BIOLOGY (2016)
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Elena V. Knatko et al.
CANCER PREVENTION RESEARCH (2015)
Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction
Helene C. Bertrand et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson's Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia
Xiqun Chen et al.
PLOS ONE (2015)
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation
Marthe H. R. Ludtmann et al.
BIOCHEMICAL JOURNAL (2014)
Monitoring Keap1-Nrf2 interactions in single live cells
Liam Baird et al.
BIOTECHNOLOGY ADVANCES (2014)
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis
Isabel Lastres-Becker et al.
BRAIN (2014)
Neurogenesis in the Striatum of the Adult Human Brain
Aurelie Ernst et al.
CELL (2014)
BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety
Robert J. Fox et al.
CURRENT MEDICAL RESEARCH AND OPINION (2014)
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
Andrea Crotti et al.
NATURE NEUROSCIENCE (2014)
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
Anne Cleasby et al.
PLOS ONE (2014)
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
John D. Hayes et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease
Navneet Ammal Kaidery et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
Liam Baird et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
An Isotopically Tagged Azobenzene-Based Cleavable Linker for Quantitative Proteomics
Yu Qian et al.
CHEMBIOCHEM (2013)
Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure-Activity Relationships
Paolo Polucci et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin
Youngnam N. Jin et al.
PLOS ONE (2013)
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration
Xiqun Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
Liam Baird et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Antioxidants in Huntington's disease
Ashu Johri et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)
Protein oxidation in Huntington disease
M. Alba Sorolla et al.
BIOFACTORS (2012)
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
Joshua A. Smith et al.
BRAIN RESEARCH BULLETIN (2012)
The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress
Andrea L. Benedict et al.
CARCINOGENESIS (2012)
Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes
CELL STEM CELL (2012)
Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells
Mahru C. An et al.
CELL STEM CELL (2012)
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
Kai Takaya et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic Modulation via Fumaric Acid Esters
De-Hyung Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Bone Marrow Transplantation Confers Modest Benefits in Mouse Models of Huntington's Disease
Wanda Kwan et al.
JOURNAL OF NEUROSCIENCE (2012)
CCG polymorphisms in the huntingtin gene have no effect on the pathogenesis of patients with Huntington's disease in mainland Chinese families
Bao-rong Zhang et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)
Multiple phenotypes in Huntington disease mouse neural stem cells
James J. Ritch et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2012)
Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity
Tracy P. Williamson et al.
NEUROTOXICOLOGY (2012)
PGC-1α Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
Taiji Tsunemi et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington's Disease Mouse Models
Vanita Chopra et al.
CELL REPORTS (2012)
The cytoprotective role of the Keap1-Nrf2 pathway
Liam Baird et al.
ARCHIVES OF TOXICOLOGY (2011)
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Ralf A. Linker et al.
BRAIN (2011)
Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview
Vincenzo Pizza et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2011)
Microglial activation in regions related to cognitive function predicts disease onset in Huntington's Disease: A multimodal imaging study
Marios Politis et al.
HUMAN BRAIN MAPPING (2011)
Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells
Kyungmi Koh et al.
JOURNAL OF NEUROIMMUNOLOGY (2011)
A Tale on Animal Models of Parkinson's Disease
Erwan Bezard et al.
MOVEMENT DISORDERS (2011)
Neurodegeneration and Inflammation in Parkinson's disease
Sudarshan Phani et al.
PARKINSONISM & RELATED DISORDERS (2011)
Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
Gisa Ellrichmann et al.
PLOS ONE (2011)
A Small-Molecule Inducer of the Antioxidant Response Element
Wooyoung Hur et al.
CHEMISTRY & BIOLOGY (2010)
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease
Cliona Stack et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Activation of NRF2 by Nitrosative Agents and H2O2 Involves KEAP1 Disulfide Formation
Simon Fourquet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Neuroinflammation in Huntington's disease
Thomas Moeller
JOURNAL OF NEURAL TRANSMISSION (2010)
Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease
Xueyi Li et al.
JOURNAL OF NEUROSCIENCE (2010)
The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants
Kyeong-Ah Jung et al.
MOLECULES (2010)
Quantitative reactivity profiling predicts functional cysteines in proteomes
Eranthie Weerapana et al.
NATURE (2010)
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
Michael McMahon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Quantitative analysis of chromatin compaction in living cells using FLIM-FRET
David Lleres et al.
JOURNAL OF CELL BIOLOGY (2009)
Does neuroinflammation fan the flame in neurodegenerative diseases?
Tamy C. Frank-Cannon et al.
MOLECULAR NEURODEGENERATION (2009)
Distinct neuroinflammatory profile in post-mortem human Huntington's disease
Aurelio Silvestroni et al.
NEUROREPORT (2009)
Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants
Edward C. Stack et al.
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
Proteomic and oxidative stress analysis in human brain samples of Huntington disease
M. Alba Sorolla et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Maria Bjorkqvist et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
The transcription factor Nrf2 is a therapeutic target against brain inflammation
Nadia G. Innamorato et al.
JOURNAL OF IMMUNOLOGY (2008)
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Veit Hornung et al.
NATURE IMMUNOLOGY (2008)
Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles
Hua Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance
Ok-Hee Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent
Aimee L. Eggler et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2007)
Different electrostatic Potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Kit I. Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
Imaging microglial activation in Huntington's disease
Yen F. Tai et al.
BRAIN RESEARCH BULLETIN (2007)
Role of complement in neurodegeneration and neuroinflammation
Domenico Marco Bonifati et al.
MOLECULAR IMMUNOLOGY (2007)
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP) - a general method for mapping sites of probe modification in proteomes
Eranthie Weerapana et al.
NATURE PROTOCOLS (2007)
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates
Annette Dalrymple et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Oxidative damage in Huntington's disease pathogenesis
Susan E. Browne et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
Kit I. Tong et al.
BIOLOGICAL CHEMISTRY (2006)
Microglial activation correlates with severity in Huntington disease - A clinical and PET study
N. Pavese et al.
NEUROLOGY (2006)
Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
K Xu et al.
JOURNAL OF NEUROSCIENCE (2006)
Inflammatory process in Parkinson's disease: Role for cytokines
T Nagatsu et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow et al.
HUMAN MOLECULAR GENETICS (2003)
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
JM Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
N Wakabayashi et al.
NATURE GENETICS (2003)
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
DTASelect and contrast: Tools for assembling and comparing protein identifications from shotgun proteomics
DL Tabb et al.
JOURNAL OF PROTEOME RESEARCH (2002)
Total syntheses of 6-and 7-azaindole derived GnRH antagonists
F Ujjainwalla et al.
TETRAHEDRON LETTERS (2001)
Early and progressive accumulation of reactive microglia in the Huntington disease brain
E Sapp et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2001)
ST14A cells have properties of a medium-size spiny neuron
ME Ehrlich et al.
EXPERIMENTAL NEUROLOGY (2001)
Rate of functional decline in Huntington's disease
K Marder et al.
NEUROLOGY (2000)
Share Paper
