Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 28, Pages 7278-7282Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1702513114
Keywords
photosensitizer; self-assembly; conjugated oligomers; photodynamic therapy; excited states
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Funding
- National Science Foundation (NSF) [NSF 1207362, NSF 1605225, NSF 1263387]
- Defense Threat Reduction Agency [HDTRA1-08-1-0053]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1263387] Funding Source: National Science Foundation
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Photodynamic therapy, in which malignant tissue is killed by targeted light exposure following administration of a photosensitizer, can be a valuable treatment modality but currently relies on passive transport and local irradiation to avoid off-target oxidation. We present a system of excited-state control for truly local delivery of singlet oxygen. An anionic phenylene ethynylene oligomer is initially quenched by water, producing minimal fluorescence and no measurable singlet oxygen generation. When presented with a binding partner, in this case an oppositely charged surfactant, changes in solvent microenvironment result in fluorescence unquenching, restoration of intersystem crossing to the triplet state, and singlet oxygen generation, as assayed by transient absorption spectroscopy and chemical trapping. This solvation-controlled photosensitizer model has possible applications as a theranostic agent for, for example, amyloid diseases.
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