Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 45, Pages E9445-E9454Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1711924114
Keywords
nanodiamonds; nanomedicine; clinical trial; biomaterial; infection
Categories
Funding
- National Research Foundation Cancer Science Institute of Singapore Research Centres of Excellence (RCE) Main Grant
- Ministry of Education Academic Research Fund (MOE AcRF) [Tier 2 MOE2015-T2-2-126]
- National University Cancer Institute (NCIS) Yong Siew Yoon Research Grant
- National Science Foundation Early Career Faculty Development Program (CAREER) Award [CMMI-1350197]
- Center for Scalable and Integrated NanoManufacturing [DMI-0327077, CMMI-0856492, DMR-1343991, OISE-1444100]
- V Foundation for Cancer Research Scholars Award
- Wallace H. Coulter Foundation Translational Research Award
- National Cancer Institute (NCI) [U54CA151880]
- Society for Laboratory Automation and Screening Endowed Fellowship
- Beckman Coulter Life Sciences
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Detonation nanodiamonds (NDs) are promising drug delivery and imaging agents due to their uniquely faceted surfaces with diverse chemical groups, electrostatic properties, and biocompatibility. Based on the potential to harness ND properties to clinically address a broad range of disease indications, this work reports the in-human administration of NDs through the development of ND-embedded gutta percha (NDGP), a thermoplastic biomaterial that addresses reinfection and bone loss following root canal therapy (RCT). RCT served as the first clinical indication for NDs since the procedure sites involved nearby circulation, localized administration, and image-guided treatment progress monitoring, which are analogous to many clinical indications. This randomized, single-blind interventional treatment study evaluated NDGP equivalence with unmodified GP. This progress report assessed one control-arm and three treatment-arm patients. At 3-mo and 6-mo follow-up appointments, no adverse events were observed, and lesion healing was confirmed in the NDGP-treated patients. Therefore, this study is a foundation for the continued clinical translation of NDs and other nanomaterials for a broad spectrum of applications.
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