Journal
HEALTH SCIENCE REPORTS
Volume 1, Issue 6, Pages -Publisher
WILEY
DOI: 10.1002/hsr2.47
Keywords
coinfection; influenza A virus; microbiome; respiratory disease; severe acute respiratory infection; upper respiratory tract
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [311309/2012-7]
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul [2282-2551/14-5]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Graduate Program in Pathology of UFCSPA
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Aims Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not infected by IAV. Methods and Results Using target sequencing of the 16S rRNA gene, we assessed the bacterial community of nasopharyngeal aspirate samples and compared the microbiome of patients infected with IAV with the microbiome of patients who were negative for IAV. We observed differences in the relative abundance of Proteobacteria and Firmicutes between SARI patients, with Streptococcus being enriched and Pseudomonas underrepresented in IAV patients compared with patients who were not infected with IAV. Conclusion Pseudomonas taxon seems to be in high frequency on the nasopharynx of SARI patients with non-IAV infection and might present a negative association with Streptococcus taxon. Microbial profile appears to be different between SARI patients infected or not infected with IAV.
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