Journal
BIOACTIVE MATERIALS
Volume 3, Issue 2, Pages 144-156Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2017.11.008
Keywords
Bioprinting; Hydrogel; Extrusion; Inkjet; Stereolithography; Laser-assisted; Review; 3D printing
Funding
- National Sciences and Engineering Research Council of Canada (NSERC)
- NSERC
- Canada Foundation for Innovation
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3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting. Other important factors include but are not limited to printing fidelity, stability, crosslinking time, biocompatibility, cell encapsulation and proliferation, shear-thinning properties, and mechanical properties such as mechanical strength and elasticity. In this review, we recite recent promising advances in bioink development as well as bioprinting methods. Also, an effort has been made to include studies with diverse types of crosslinking methods such as photo, chemical and ultraviolet (UV). We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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