Journal
BIOMEDICAL REPORTS
Volume 8, Issue 5, Pages 399-406Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2018.1077
Keywords
survivin; cancer; programmed cell death; target therapy
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Survivin, also known as baculoviral inhibitor of apoptosis repeat-containing 5, is a novel member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors and embryonic tissues and is associated with tumor cell differentiation, proliferation, invasion and metastasis; however, survivin is expressed at low levels in normal terminally differentiated adult tissues. Meanwhile, the expression level of survivin is also a negative prognostic factor for patients with cancer. These unique characteristics of survivin make it an exciting potential therapeutic target for cancer treatment. This review will discuss the biological characteristics of survivin and its potential use as a treatment target to reduce cancer cell proliferation.
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