Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 5, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1074335
Keywords
apoptosis; crosstalk; DNA damage; HIPK2; nuclear body; PML; p53; SIRT1
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB 1036]
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Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage. Regulation of p53 activity by posttranslational modifications has been linked to promyelocytic leukemia nuclear bodies (PML-NBs), where p53 encounters many of its regulators. Recent evidence implies that crosstalk between p53 regulators at the PML-NB shapes post-translational modifications and function of p53.
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