3.8 Article

Loss of histone acetylation and H3K4 methylation promotes melanocytic malignant transformation

Journal

MOLECULAR & CELLULAR ONCOLOGY
Volume 5, Issue 3, Pages -

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2017.1359229

Keywords

Benign; chromatin states; epigenome; histone modifications; malignant; melanoma; nevi

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Epigenetic mechanisms play essential roles in biological processes such as cell maintenance, differentiation, proliferation and apoptosis. A recent report from our laboratory showed that the loss of histone acetylation and H3K4 (Histone H3 Lysine 4) methylation in the proximal regions of cancer regulatory genes promote tumorigenesis.

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