Journal
CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM
Volume 7, Issue 1, Pages 4-9Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/XCE.0000000000000141
Keywords
atherosclerosis; cardiovascular disease; cell signaling; cholesterol toxicity; diabetes mellitus; dyslipidemia; epigenetics; glucose toxicity; inflammation; pathophysiology
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Diabetes mellitus elicits cellular, epigenetic, and post-translational changes that directly or indirectly affect the biology of the vasculature and other metabolic systems resulting in the apparition of cardiovascular disease. In this review, we provide a current perspective on the most recent discoveries in this field, with particular focus on hyperglycemia-induced pathology in the cardiovascular system. We also provide perspective on the clinical importance of molecular targeting of cardiovascular and diabetes mellitus therapies to treat hyperglycemia, inflammation, thrombosis, dyslipidemia, atherosclerosis, and hypertension. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.
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