Journal
JOURNAL OF MICRO-BIO ROBOTICS
Volume 14, Issue 1-2, Pages 35-40Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s12213-018-0104-3
Keywords
Solid-state nanopore; Conical nanopore; Dielectric breakdown; DNA sequencing
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Funding
- Chinese Academy of Sciences [Y52A100K10]
- National Nature Science Foundation of China [61471336]
- Joint-Scholar of West-Light Foundation of the Chinese Academy of Sciences
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Solid-state nanopore is a promising alternative for current nucleic acid analysis in DNA sequencing. In this work, we employed current-stimulus dielectric breakdown to fabricate a 2 nm nanopore on SiNx membrane. The effect of this 2 nm SiNx nanopore was then examined by comparing the translocation behaviors of four types of ssDNA through this nanopore. Current signal collected from the nanopore can distinguish the four types of ssDNA with 30 nucleobases and 100 nucleobases, providinginformation about the sequence and structure of the ssDNA molecule.
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