Many Flavors of Model-Based Meta-Analysis: Part II - Modeling Summary Level Longitudinal Responses

Meta-analyses typically assess comparative treatment response for an end point at specific timepoints across studies. However, during drug development, it is often of interest to understand the response time-course of competitor compounds for a variety of purposes. Examples of such application include informing study design and characterizing the onset, maintenance, and offset of action. This tutorial acts as a points for consideration document, reviews relevant literature, and fits a longitudinal model to an example dataset.