Journal
ENVIRONMENT INTERNATIONAL
Volume 83, Issue -, Pages 11-40Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2015.05.012
Keywords
Endocrine disruptor; Estrogen action; Molecular mechanism; Techonology; Signal transduction; Toxicity pathway
Categories
Funding
- Knowledge Cluster Initiative program
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Guideline Program for Medical Device Development from the Ministry of Economy, Trade and Industry of Japan
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A comprehensive summary of more than 450 estrogenic chemicals including estrogenic endocrine disruptors is provided here to understand the complex and profound impact of estrogen action. First, estrogenic chemicals are categorized by structure as well as their applications, usage and effects. Second, estrogenic signaling is examined by the molecular mechanism based on the receptors, signaling pathways, crosstalk/bypassing and autocrine/paracrine/homeostatic networks involved in the signaling. Third, evaluation of estrogen action is discussed by focusing on the technologies and protocols of the assays for assessing estrogenicity. Understanding the molecular mechanisms of estrogen action is important to assess the action of endocrine disruptors and will be used for risk management based on pathway-based toxicity testing. (C) 2015 Elsevier Ltd. All rights reserved.
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