Journal
POLYMER CHEMISTRY
Volume 8, Issue 10, Pages 1680-1688Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6py02243j
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Funding
- National Natural Science Foundation of China [21274121, 21674094, 51603180]
- Key Project of Natural Science Foundation of Zhejiang Province [LZ16H140001]
- China Postdoctoral Science Foundation [2015 M580517]
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Dendron-like multifunctional beta-cyclodextrin-poly(ethylene glycol) (CD-PEG) conjugates were synthesized from amino functionalized beta-cyclodextrins and poly(ethylene glycol) diacrylate through the Michael addition reaction. The resultant conjugates contain several PEG arms terminated with acrylates, which originated from the same glucopyranose unit of CD. These dendron-like CD-PEG conjugates can incorporate adamantane-modified doxorubicin (AD-DOX) by host-guest interactions between CD and AD moieties, to give a reactive supramolecular polymeric prodrug, which can be further crosslinked by poly[oligo(ethylene glycol) mercaptosuccinate] (POEGMS) via thiol-ene click reaction under physiological conditions. These kinds of in situ forming drug-loaded hydrogels can be utilized as injectable gelling carriers for localized drug delivery.
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