Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 50, Issue 6, Pages 605-614Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmy049
Keywords
miR-23b-3p; EBF3; epithelial-to-mesenchymal transition (EMT); esophageal squamous cell carcinoma (ESCC)
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Funding
- Hubei Province Health and Family Planning Scientific Research Project [WJ2016-Y-08]
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MicroRNAs (miRNAs), some small non-coding RNAs that regulate gene expression at the posttran-scriptional level, are always aberrantly expressed in carcinomas. In this study, we found that miR-23b-3p was remarkably up-regulated in human esophageal squamous cell carcinoma cells and tissues. Moreover, miR-23b-3p could induce the proliferation, invasion, and metastasis in vitro. EBF3 was identified as the direct downstream target gene of miR-23b-3p and ectogenic EBF3 could strongly inhibit the proliferation, invasion, and metastasis in vitro. Furthermore, it was found that miR-23b-3p could regulate epithelial-to-mesenchymal transition progress by blocking EBF3. Therefore, it was concluded that miR-23b-3p targeted EBF3 to accelerate the proliferation, invasion, and metastasis in ESCC.
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