TNF-α/IL-10 ratio: An independent predictor for coronary artery disease in North Indian population

Background/Aim: Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of coronary artery disease (CAD). Tumor necrosis factor-alpha (TNF-alpha) are considered as a pro inflammatory and interleukin-10 (IL-10) anti inflammatory have been shown to predict the risk of incident of CAD. Aim of present study is to examine the impact of the TNF-alpha and Il-10 levels on various components of the CAD. Methods: Total 580 subjects were recruited in the present study out of which 290 diagnosed CAD subjects (Age 51.61 +/- 9.26; BMI 25.27 +/- 3.58) and 290 healthy controls (Age 51.72 +/- 9.48; BMI 24.02 +/- 7.42). Serum TNF-alpha and IL-10 levels were measured by ELISA. Results: Data of present study revealed that CAD patients had higher frequency (p=0.001) of smoking (38.28%), Alcohol (21.03%), Diabetes (53.45%) and hypertension (48.28%) as compare to controls. Moreover, we have observed highly significant (p<0.05) difference in PR, BMI, DBP, DBP, Glucose, TC, TG, VLDL, LDL, TNF-alpha and TNF-alpha/IL-10. However, HDL and IL-10 were found lower in CAD. Conclusion: The findings of present study suggest that the TNF-alpha/IL-10 ratio may play a vital role in the development of CAD of North Indian population. (C) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.