Journal
POLYHEDRON
Volume 124, Issue -, Pages 117-124Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2016.12.039
Keywords
Copper complexes; Electrochemical analysis; Biological studies; Drug-DNA interaction
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Four novel copper complexes bis((E)-2-((4-phenoxyphenylimino)methyl)phenolate) copper(II) (CuL1), bis ((E)-2-((4- (4-biphenyloxy)phenylimino)methyl)phenolate) copper(II) (CuL2), bis((E)-2-((4-(naphthalen1-yloxy)phenylimino)methyl)phenolate) copper(II) (CuL3) and bis((E)-2-((4-(2-naphthoxy)phenylimino) methyl)phenolate) copper(II) (CuL4) have been synthesized and characterized by FTIR spectroscopy, elemental analysis and electro-analytical techniques. Single crystal X-ray diffraction analysis of complex (CuL1) revealed that the compound crystallizes in the orthorhombic crystal system. The absolute structure has been determined from the diffraction data. The molecule lies on a 2-fold axis with geometry intermediate between square planar and tetrahedral. In the complexes the ligands are bidentate, coordinating through phenolate oxygen and azomethine nitrogen to the copper ions. The biological studies (cytotoxic and antitumor) have revealed their bioactive nature. Results of brine shrimp cytotoxicity indicated their LD50 values < 1 mu g/ml and IC50 values from 0.7 to 16 mu g/ml, indicating their antitumor nature. The voltammetric analysis showed that the complexes follow one electron transfer quasi-reversible partially diffusion controlled process. Further, the electro-reduced form of the complexes had substantial interaction with DNA molecules in a concentration dependent manner. (C) 2017 Elsevier Ltd. All rights reserved.
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