Synthesis, characterization, cytotoxicity and antimicrobial studies on Bi(III) dithiocarbamate complexes containing furfuryl group and their use for the preparation of Bi2O3 nanoparticles

Bismuth(III) dithiocarbamate complexes, tris(N-furfuryl-N-propyldithiocarbamato-S,S')bismuth(III) (1), tris(N-furfuryl-N-butyldithiocarbamato-S,S')bismuth(III) (2) and tris(N-furfuryl-N-benzyldithiocarbamato-S,S')bismuth(III) (3), have been prepared and characterized by microanalysis, and spectroscopy (IR and NMR). Structure of 3 has been obtained by single crystal X-ray diffraction. This complex contains distorted pentagonal pyramidal Bi(III) centres which attain an overall distorted pentagonal bipyramidal coordination via long range intermolecular Bi center dot center dot center dot S interactions. DFT quantum mechanical studies of 3 were carried out, supporting the partial double bond character of C-N (thioureide) and C-S bonds in dithiocarbamate ligands. All the compounds have been screened against a panel of microbes viz. Vibrio cholerae, Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Aspergillus niger and Candida albicans. Complexes 1 and 3 were found to have better activity against K. pneumoniae, V. cholerae, A. niger and C. albicans than the complex 2. Complexes 1-3 have been evaluated for their in vitro cytotoxic activity against KB cells. Complexes 1 and 3 showed higher activity than 2. Bi2O3 obtained from thermal decomposition of 3 has been characterized by PXRD, HRTEM, EDAX, UV-Vis and Fluorescence spectroscopy. PXRD study showed that the sample is composed of monoclinic phase of alpha-Bi2O3. Photocatalytic activity of as-prepared alpha-Bi2O3 was determined by decolourization of rhodamine-B in aqueous solution under ultra violet irradiation. (C) 2016 Elsevier Ltd. All rights reserved.