Journal
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
Volume 26, Issue 5, Pages 2085-2094Publisher
HARD
DOI: 10.15244/pjoes/69251
Keywords
metallic nanoparticle; combined toxicity; biomarker response; IBRv2; Carassius auratus
Categories
Funding
- National Natural Science Foundation of China [51509071]
- Natural Science Foundation of Jiangsu Province, China [BK20150801]
- National Science Funds for Creative Research Groups of China [51421006]
- National College Students Innovation Experiment Program of Hohai University [201610294043]
- TAPP [PPZY2015A051]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Although study of the toxicity of metallic nanoparticles in aquatic organisms is increasing, there is still little known about their combined toxicity, especially in a comparative and integrated approach. The objective of this study is to compare the toxicity of copper nanoparticles (CuNP), chromium nanoparticles (CrNP), and their mixtures to crucian carp (Carassius auratus) through a comprehensive approach. A high median lethal concentration of CuNP (390.75 mg/L) and CrNP (551.03 mg/L) was calculated from the acute toxicity, indicative of low toxicity to crucian carp. After exposure for 10 d at sublethal concentrations, several biomarker responses, including the activities of brain acetylcholinesterase (AChE), gill sodium/ potassium-activated ATP (Na+/K+-ATP), liver superoxide dismutase (SOD), and catalase (CAT) were significantly inhibited by all nanoparticles in most cases, implying the neurotoxicity, osmoregulatory toxicity, and oxidative damage of metallic nanoparticles. Thereafter, the integrated biomarker response version 2 (IBRv2) integrating all biomarker responses was applied to compare the toxicity, and therefore the toxicity order was tentatively proposed as: the mixtures approximate to CuNP square CrNP, suggesting a synergistic effect in the mixtures. The findings will help to understand the ecological impacts of metallic nanoparticles in an aquatic environment in a more complete and accurate picture.
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