Journal
BRAIN CIRCULATION
Volume 4, Issue 3, Pages 118-123Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/bc.bc_15_18
Keywords
Myelination; neurovascular unit; oligodendrocyte; oligodendrocyte precursor cell; white-matter repair
Categories
Funding
- National Institutes of Health
Ask authors/readers for more resources
There are currently no adequate treatments for white-matter injury, which often follows central nervous system maladies and their accompanying neurodegenerative processes. Indeed, the white matter is compromised by the deterioration of the blood-brain barrier and the demyelination of neuronal axons. Key repairs to the white matter are mediated by oligodendrocyte lineage cells after damaging events. Oligodendrocytes are supported by other cells in the neurovascular unit and these cells collaborate in processes such as angiogenesis, neurogenesis, and oligodendrogenesis. Understanding the various interactions between these cells and oligodendrocytes will be imperative for developing reparative therapies for impaired white matter. This minireview will discuss how oligodendrocytes and oligodendrocyte lineage cells mend damage to the white matter and restore brain function ensuing neural injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available