Journal
GUT MICROBES
Volume 9, Issue 1, Pages 68-75Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2017.1356979
Keywords
beta diversity; GWAS; human gut microbiota; immunity; IBD
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Funding
- German Research Foundation (DFG) Collaborative Research Center (CRC) 1182, Origin and Function of Metaorganisms
- DFG Excellence Cluster 306, Inflammation at Interfaces
- German Federal Ministry of Education and Research (BMBF)
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Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the beta diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-beta-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in b diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota.
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