Association between vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study

Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25 hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25 hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 +/- 0.71 mL/min/ 1.73 m(2). We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25 hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25 hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (beta= 0.147, p= 0.003 and beta= 0.151, p= 0.047). In conclusion, there was a significant association between serum 25 hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.