Journal
CELL AND TISSUE RESEARCH
Volume 373, Issue 1, Pages 137-148Publisher
SPRINGER
DOI: 10.1007/s00441-017-2706-9
Keywords
Alpha-synuclein; Multiple system atrophy; Dementia with Lewy bodies; Parkinson's disease; Ordered assembly
Categories
Funding
- UK Medical Research Council
- Alzheimer's Research UK
- Gates International
- Astra Zeneca
- Cambridge Biomedical Centre
- Addenbrooke's Hospital Trust
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Horizon 2020 IMPRiND
- UK Medical Research Council [MC_U105184291]
- EU Joint Programme - Neurodegenerative Disease Research
- EPSRC [EP/P008224/1] Funding Source: UKRI
- MRC [MC_U105184291] Funding Source: UKRI
- Alzheimers Research UK [ART-PG2011-20] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/P008224/1] Funding Source: researchfish
- Medical Research Council [MC_U105184291] Funding Source: researchfish
- Parkinson's UK [G-0701, G-1102] Funding Source: researchfish
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In 2017, it was 200 years since James Parkinson published 'An Essay on the Shaking Palsy' and 20 years since alpha-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. Here, we describe the work that led to the identification of alpha-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies. We also review some of the findings reported since 1997.
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