Journal
ALLERGY
Volume 70, Issue 9, Pages 1184-1188Publisher
WILEY-BLACKWELL
DOI: 10.1111/all.12662
Keywords
basophil extracellular trap; basophils; extracellular bacterial killing; innate immunity; phagocytosis
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Funding
- Swiss National Science Foundation [310030_146215, 310030_146181]
- Swiss National Science Foundation (SNF) [310030_146215, 310030_146181] Funding Source: Swiss National Science Foundation (SNF)
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Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
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