Journal
BIOMEDICINES
Volume 6, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines6020048
Keywords
neuroprotection; Rhus coriaria; linoleic acid; ischemic optic neuropathy; anti-neuroinflammation
Categories
Funding
- EMAN laboratory at the University of Science Malaysia
Ask authors/readers for more resources
Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and -carotene were 6.79 +/- 0.009 mu g/mL, 10.94 +/- 0.09 mu g/mL, and 6.25 +/- 0.06 mu g/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available