Journal
PLASMA PROCESSES AND POLYMERS
Volume 15, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201700077
Keywords
atmospheric pressure plasma; membrane transport; non-thermal plasma; OH radical; Pockels cell
Funding
- Research Institute of Electrical Communication, Tohoku University
- Japan Society for the Promotion of Science [15J01427, 15K17480, 16K13708, 24108004]
- Knowledgebased Medical Device Cluster/Miyagi Area
- Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
- Grants-in-Aid for Scientific Research [16K13708] Funding Source: KAKEN
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Despite the promising potential of medical treatments based on non-equilibrium atmospheric-pressure plasma, most of the underlying mechanisms remain unknown. Here we report that direct plasma irradiation (DPI) can induce transient increase in intracellular calcium (Ca2+) concentrations, thereby playing key roles in many cellular processes as well as the uptake of middle-size membrane-impermeable molecules, which did not occur with indirect plasma irradiation (IPI). Experimental measurements using a Pockels voltage probe and gelling chemical reagent showed that electric field of 150 kV/cm and hydroxyl radical (OH) supply to cell cultures were induced by DPI under a typical condition compared with IPI. In addition, significant inhibition of the OH scavenger D-mannitol indicated involvement of OH in those DPI-induced cellular responses. These results facilitate the elucidation of plasma-cell interaction and the development of plasma devices for medical treatments.
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