Journal
PLASMA PROCESSES AND POLYMERS
Volume 14, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201700014
Keywords
3D scaffold; eukaryotic cells; PAM; Plasma Medicine; RONS; Tissue Engineering
Funding
- RINOVATIS (PON MIUR)
- LIPP (Rete di Laboratorio, Regione Puglia) [51]
- RIGENERA (partnernariati Regione Puglia)
- SISTEMA (PON MIUR)
- EC COST action [MP1101]
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Cold plasmas are continuously developed for biomaterials engineering as well as for therapeutic treatments of cells and tissues. For this last application plasma activated media (PAM) and reactive oxygen and nitrogen species (RONS) gained attention as key players. Here, the use of cold atmospheric pressure (AP) plasma is described, for generating RONS in Dulbecco's Modified Eagles Medium (DMEM); superoxide anion (O2-), hydrogen peroxide (H2O2), nitrates (NO3-), and nitrites (NO2-) were detected. PAM was applied to Bone Marrow Stem Cells (BMSC) and SAOS-2 osteoblasts. Both native and plasma-modified polymeric scaffolds were used as three dimensional (3D) supports for cell cultures. The cell activity was found dependent on both PAM and cell type. BMSCs grown on plasma-coated scaffolds tolerated better PAM with respect to those on native scaffolds.
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