Journal
FRONTIERS IN MEDICINE
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2018.00193
Keywords
rheumatoid diseases; long non-coding RNAs; rheumatoid arthritis; systemic lupus erythematosus (SLE); Sjogren's syndrome
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Funding
- National Natural Science Foundation of China [81571593]
- Institute of Psychiatry and Neurology, Xinxiang Medical University
- Deutsche Forschungsgemeinschaft, German Center for Lung Research (DZL)
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Rheumatoid diseases are a group of systemic autoimmune diseases which affect multiple organs with largely unknown etiology. In the past decade, long non-coding RNAs (lncRNAs) have emerged as important regulators of biological processes and contribute deeply to immune cell development and immune responses. Substantial evidences have been accumulated showing that LncRNAs involved in the pathogenesis of the rheumatoid diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS). In this review, we summarize literature combined with bioinformatics methods to analyze the unique and common lncRNAs patterns in rheumatoid diseases and try to reveal the important function of lncRNAs in RA, SLE and SS.
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