Journal
ACS APPLIED BIO MATERIALS
Volume 1, Issue 1, Pages 110-117Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00029
Keywords
porphyrin; nanomaterials; photoacoustic imaging; photodynamic therapy; two-photon irradiation
Funding
- National Natural Science Foundation of China (NSFC) [21601142]
- Natural Science Foundation of Hubei Province [2017CFB689]
- Hong Kong Research Grants Council [HKBU 22304115]
- Faculty Research Grants [FRG2/14-15/034, FRG1/14-15/058]
- Interinstitutional Collaborative Research Scheme [RC-ICRS/15-16/02E, RC-ICRS/1617/02C-CHE]
- Interdisciplinary Research Matching Scheme [RC-IRMS/16/17/02CHEM]
- Innovative Scientific Research Team Introducing Project of Zhongshan City [2015-224]
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The incorporation of intensive light absorbing porphyrins macrocycles with biocompatible nanoparticles would lead to new nanomaterials with multiple imaging and therapeutic modalities. Herein, a facile synthetic strategy has been applied to prepare porphyrin-implanted carbon nanodots (PNDs) by partial and selective pyrolysis of 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP) and citric acid (CA) at an appropriate temperature. As-prepared PNDs exhibit not only the excellent stability and biocompatibility characteristic of carbon nanodots but also the unique properties of porphyrin macrocycle such as strong UV-visible and near-infrared absorption, specifically, high photodynamic therapy efficiency. More importantly, the PNDs with near-infrared absorption could act as a contrast agent for photoacoustic molecular imaging with deep tissue penetration and fine spatial resolution. The Cetuximab-conjugated porphyrin-based carbon nanodots (C225-PNDs) have been further prepared to precisely target the cancer cells (HCC827 and MDA-MB-231 cells) with overexpression of EGFR, leading to highly efficient photodynamic therapy upon two-photo excitation at 800 nm. A complete ablation of tumor together with an enhanced photoacoustic contrast ability for C225-PNDs have been further validated in mice bearing MDA-MB-231 breast cancer.
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