Journal
ACS APPLIED BIO MATERIALS
Volume 1, Issue 1, Pages 27-32Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00046
Keywords
conjugated polymer nanoparticles; photothermal conversion; NIR; bacterial infections; antimicrobial therapy
Funding
- National Nature Science Foundation [21571116]
- Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi [2017-07]
- SanJin Scholars Support Plan [2017-06]
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The emergence of drug-resistant bacterial strains makes antimicrobial treatment a big challenge. Thus, more novel and effective antimicrobial agents and treatments are urgently desired. Herein, we developed a facile and rapid photothermal antimicrobial nanoplatform based on near-infrared (NIR)-active and photothermal-responsive conjugated polymer nanoparticles (CPNs) functionalized with cell-penetrating peptide (CPNs-Tat). With a positively charged Tat peptide, CPNs-Tat could enhance the interaction with bacteria cells with the formation of CPNs-Tat/bacteria aggregation. Under NIR irradiation, CPNs-Tat could convert the light into heat efficiently and produce local hyperthermia to kill bacteria within a few minutes. This photothermal-responsive strategy offers a rapid and effective modality for combating bacterial infections.
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