Journal
LUNG CANCER-TARGETS AND THERAPY
Volume 9, Issue -, Pages 35-43Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/LCTT.S124483
Keywords
Hedgehog pathway; transcriptional regulator; lung cancer; inhibitors
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Funding
- Italian Association for the Cancer Research (AIRC): My First AIRC Grant (MFAG) [17083]
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GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non-small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies.
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