Journal
JOURNAL OF DIABETES INVESTIGATION
Volume 9, Issue 4, Pages 875-881Publisher
WILEY
DOI: 10.1111/jdi.12774
Keywords
Hypertension; Sodium-glucose cotransporter inhibitor; Thiazide diuretics
Categories
Funding
- Sanofi
- Novo Nordisk
- Lilly
- Boehringer Ingelheim
- MSD
- Takeda
- Ono Pharma
- Daiichi Sankyo
- Sumitomo Dainippon Pharma
- Mitsubishi Tanabe Pharma
- Pfizer
- Kissei Pharma
- AstraZeneca
- Astellas
- Novartis
- Kowa
- Chugai
- Taisho Pharma
- Novo Nordisk Pharma
- Sanwa Kagaku Kenkyusho
- Taisho Pharmaceutical Co., Ltd
- Nippon Boehringer Ingelheim Co., Ltd
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Aims/IntroductionSodium-glucose cotransporter 2 (SGLT2) inhibitors function to increase urinary glucose excretion and improve glycemic control in individuals with type 2 diabetes mellitus. SGLT2 inhibitors, as well as diuretics, increase urinary volume, which leads to the reduction of blood pressure. The aim of the present study was to compare the effects of SGLT2 inhibitor and thiazide diuretic on blood pressure, metabolic parameters and body mass composition. Materials and MethodsA total of 31 participants were enrolled in the present study. We switched from thiazide diuretics to an SGLT2 inhibitor, ipragliflozin, in participants with type 2 diabetes and hypertension whose blood pressure was controlled with thiazide diuretics. Three months after the switch, we evaluated the effects of such switching on blood pressure, various metabolic parameters and body mass composition. ResultsThere was no significant difference in blood pressure from baseline to 3 months later. However, glycated hemoglobin, fasting plasma glucose and uric acid were significantly decreased after the switch. Body mass index and visceral fat area were also significantly reduced after the switch. Furthermore, urinary albumin excretion was also significantly decreased after the switch. ConclusionsSwitching from thiazide diuretic to an SGLT2 inhibitor, ipragliflozin, markedly improved various metabolic parameters and body mass composition without affecting blood pressure in participants with type 2 diabetes and hypertension.
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